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Background: To investigate the common symptoms after Covid-19 infection, characteristics of adverse events after vaccination, changes in clinical manifestations related to Neurofibromatosis type 1 (NF1), as well as the current vaccination status and factors related to vaccine hesitation among NF1 patients, in order to provide a basis for scientific protection and vaccine acceptance in NF1 individuals in the new phase of pandemic management. Method(s): From December 29, 2022, to January 10, 2023, we conducted a self-assessment questionnaire survey among diagnosed NF1 patients. General data were provided including sex, age, main clinical presentations, and current treatment. This study mainly focused on the infection and vaccination status of Covid-19 among these patients with NF1. The data were statistically analyzed using SPSS26.0 software. Result(s): Of the 250 questionnaires distributed, 226 were valid. Among the 164 patients (72.6%) with Covid-19 infection, the most common infection symptoms and incidence of patients were not significantly different from those in the normal population (P>0.05), but the incidence of symptoms such as nasal congestion, headache, myalgia, sore throat, abdominal pain, diarrhea, and eye discomfort was higher than that in the normal population (P<0.05), and no severe infection was observed;186 patients (82.3%) had completed the Covid-19 vaccination, and more than half of those who were not vaccinated had no plans for vaccination. Among the vaccinated patients, there was no significant difference in the incidence of adverse events, such as fever, pain, redness, and swelling at the injection site after vaccination, compared to the normal population (P>0.05), but the incidence of fatigue and headache was higher in NF1 patients (P<0.001). Most patients with NF1 believe that there is no significant progressive change in NF1-related clinical manifestations after Covid-19 infection and vaccination. Conclusion(s): Currently, some NF1 patients appear to be worried about the evolution of their disease after Covid-19 infection in the face of large fluctuations in the pandemic situation, and some patients hesitate to receive the vaccine due to their special disease condition. Thus, clinical trials should be conducted to develop a refined pandemic response and vaccination program for this special group.Copyright © 2023 China Medical Cosmetology Press Co. Ltd.
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Introduction: COVID-19, a new coronavirus illness, swiftly spread throughout all continents. However, evidence on all of COVID-19's indications and symptoms is lacking. Patients who have COVID-19 may be more susceptible to fungal infections. Mucormycosis is an uncommon and frequently fatal fungal illness caused by hyphae invading the bloodstream and causing thrombosis and necrosis. Material(s) and Method(s): Patients diagnosed with mucormycosis following a recent COVID-19 infection were included in the case series analysis. Surgical therapy was limited to individuals who tested negative for COVID-19 on PCR. To remove the infection, endoscopic, open, and combination techniques were used. For the first month after surgery, survivors were followed up on on a regular basis. Result(s): About 30 people with a history of Covid-19 were given dexamethasone and remdesivir in this study. Following therapy, these individuals developed mucormycosis, which was treated by Functional Endoscopic Sinus Surgery (FESS). As a consequence, 16 patients (53.34 %) had numerous operations. The most prevalent related condition was diabetes mellitus (60 %). The majority of the patients were men (60 %). Our patients had an average age of 55.53+/-8.093. 43.34 % of the people died. Conclusion(s): In conclusion, mucormycosis is a rare but critical problem complicating the later part of the clinical course of COVID-1, possibly due to improper drug usage during Covid treatment. Copyright © 2023 Authors. All rights reserved.
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Purpose: To evaluate how covid-19 protective measures in Greece, especially teleworking and use of face masks, affect dry eye syndrome (DES) in contact lens (CLW) and non-contact lens (non-CLW) wearers. Method(s): In this cross-sectional study, two specially modified and reliable (Cronbach's Alpha) questionnaires were distributed electronically. The effects of teleworking, use of face masks and their combination on DES were studied. Amongst others, face mask use and duration, change of workplace and type of CL used were investigated. ANOVA statistics, x2 tests and non-parametric tests were performed. Result(s): 121 subjects completed the study, 44 CLW and 77 non-CLW. In the CLW group, teleworking showed statistically significant higher DES (p = 0.011). Additionally, dryer workplace (p = 0.007) and use of frequent replacement contact lenses (CL) other than monthlies (p = 0.014) increased DES. In the non-CLW group, teleworking (p < 0.0001) and the combination of teleworking and use of face masks (p = 0.003) showed statistically significant higher DES. Longer teleworking hours led to higher DES (p = 0.034) and higher eye discomfort (p = 0.015);when this was combined with face masks, the eye discomfort was even higher (p = 0.038). Finally, in between CLW and non-CLW, when they were under the combination of teleworking and face mask use, a statistically significant difference in eye discomfort (p < 0.0001) and in eye dryness (p = 0.010) was found, with very intense symptoms (p = 0.007 and 0.009 respectively). Conclusion(s): Analogous to international studies, face mask use and lengthy use of electronic devices led to elevated DES in both CLW and non-CLW;the novelty of this study is that examines also the two in combination. The even higher eye discomfort found should motivate CL practitioners to inform CLW and non-CLW better during this covid-19 pandemic. Copyright © 2022
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PURPOSE: Lockdown guidelines during COVID-19 pandemic increased the e-learning methods and gadgets use, basically to undergo classes, recreation procedures and media news updates, which subsequently upsurgedasthenopic symptoms as digital eye strain (DES) epidemic amid COVID-19 lockdown. This is a descriptive cross-sectional questionnaire based study which is aimed to assess the prevalence, risk factors.Pattern of gadgets used, screen time and symptomatology of Digital eye strain among medical students, teaching doctor faculties and paramedical staff during COVID-19 lockdown at BBMCH, Balangir. METHODS: This e-filled self survey analysed 570 responses from medical students of online classes(200), teachers of online classes (38), paramedical staff (122) and general population(210) .Aprevalidated CVS-Q and OSDI questionnaire regarding screen time spent, was used to calculate the DES score. Median DES Score was compared by medians or non-parametric tests. Categorical variables were compared by Chi Square test and predictors of DES were found by binary logistic regression. SPSS Version 21.0 was used to interpret and analyse the collected data. RESULTS: Majority of survey participants(78%) had at least one symptom of digital eye stain;The reported symptoms during electronic device usage in decreasing frequency were Eye fatigue(65%), Eye strain(52%), Ocular discomfort(50%), headaches(48%), Burning eyes(42%), and Dry eyes(35%), watering(34%), shoulder pain(30%) DES symptoms were found to be more than that of dry eye symptoms. The prevalence of DES in students taking e-learning surpassed to those found with other health staff and general population. DES score was also observed to be on higher side for more screen time users, use of gadgets in dark, screen distance<25cm. Lens or spectacle users suffered worsening of vision and needed change of glasses. No association between DES and exacerbation of pre-existing dry eyes and eye diseases were appreciated due to exclusion of such participants from our survey. CONCLUSION:Eye care tips are needed at periodic intervals to create awareness and to reduce eye strain symptoms, closing of eyes on regular basic, maintaining reading distance between 25-30cm and reducing screen time by breaks can lessen the prevalence of DES. As because, use of gadgets were the major media for learning or communication, so ocular health, hygiene and practical precautions should be kept in mind.
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The World Health Organization (WHO) has declared the 2019–20 coronavirus outbreak a Public Health Emergency of International Concern (PHEIC). Covid-19infection is an ongoing pandemic with high morbidity and mortality, spread from one infected personto another through respiratory airway droplets.Covid-19circulatesin many organs, including the heart, kidneys, brain, etc.Ocular symptoms, along with other symptoms, may help diagnose COVID-19. Covid-19 ocular signs of dry eyes, weeping, itching, redness, eye discomfort, foreign body feeling, elevated CRP, Procalcitonin (PCT), and erythrocyte sedimentation rate (ESR) levels, indicating an immunologic response and disease severity. There was a positive correlation between high temperature and visual symptoms.
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Introduction: The outbreak of the novel coronavirus disease (COVID-19), a highly contagious and deadly infection. Aim: To evaluate the epidemiological pattern and spectrum of the covid ocular morbidity and appraise the typical presentation of ocular manifestations in hospitalized covid patients. Methods: A prospective, cross-sectional study was conducted on individuals, who were hospitalized for COVID treatment between May 2021 and June 2021. The Data on patient history, physical exam, thorough ocular examination, laboratory results, and hospital disposition were collected and analyzed. Results: A total of 658 patients were included. Ocular signs and symptoms were noted in 162 (24.62%) patients. 51.6% patients wereof >50 years of age and 54.1% were males. 71.6% of them belonged to urban community.75.3% patients developed ocular discomfort with in acute (<1 week) period of covid infection. The most common ocular abnormality was watering with conjunctival irritation, followed by conjunctival injection and lid swelling. Among the 162 patients, 30 (79.0%) developed ocular involvement prior to day 30 of onset of their COVID symptoms. 56.7% patients relieved from ocular discomfort after treatment. 5.7% patients reported deterioration of visual acuity. 65.8% patients reported ocular discomfort associated with regular oxygen mask wearing. Most significant ocular morbidity was black discoloration of lids and peri ocular skin, lid swelling, and redness and purulent discharge of conjunctivitis needed emergency ophthalmic reference. Conclusion: spectrum of covid sore eyes extends from ocular irritation to mucormycosis and other long-term complications.